Brock Purdy’s likely absence looms large as San Francisco visits New Orleans, nudging Kyle Shanahan to lean on the run and Christian McCaffrey while M. Jones steps in to see how far the system can carry a backup.

The Saints counter with Alvin Kamara handling early-down workload and Ricky Pearsall stepping into a bigger pass-game role, supported by Brandon Cooks and Rashid Shaheed in the WR mix. George Kittle’s hamstring and Trent Williams’ health shape the game’s passing lanes and protection, making this a trench-forward, grind-it-out affair with fantasy implications everywhere.

Expect SF to stack the box and feed McCaffrey, while New Orleans tries to tilt the field through Kamara and Pearsall in quick-hitting throws. The outcome hinges on the run game, turnover avoidance, and which offense can sustain drives behind reshuffled personnel and a splintered receiving corps.